EvolutionaryScale

Defining a new frontier in protein sequence modeling, ESM Cambrian delivers breakthrough performance and efficiency. A parallel model family to our generative flagship ESM3, Cambrian sets a new state of the art for representation learning. Biology is fundamentally programmable. Every living organism shares the same genetic code across the same 20 amino acids—life’s alphabet. ESM3 understands all of this biological data, translates it, and speaks it fluently to be used as a generative tool. Fluorescent Proteins are beautiful in their complexity. They are responsible for vibrant colors in jellyfish and corals, and have become a powerful tool in biology. With ESM3 we were able to design esmGFP, a novel version of the Green Fluorescent Protein.