Retro Biosciences

In the US ~90% healthcare spending–over $3 trillion–goes toward age-related diseases. This trend is echoed worldwide. The underlying causes of age-related diseases are the mechanisms of aging itself. We focus on cellular drivers of aging to design therapeutics that will eventually prevent & reverse age-related diseases. Developments like single-cell multi-omics, pooled perturbations, and targeted delivery systems enable us to intervene in aging processes. We identify aging mechanisms for which interventions have shown robust proofs of concept in mammals and have a feasible path to translation to humans.